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My setup was almost the same Windows 64 bits and Domino 8.5.2 FP1.
After some dayes or after TSM full backup the server starts swapping a lot. Getting very slow.
Page Faults ( non-cached memory reads) is growing on new processes.
My statrep is showing Platform.Memory.RAM.PctUtil is about 63 %, just after OS reboot, but steady growing.
Sysinternals RamMap is showing a huge memmory allocation on "Mapped File".
With 9.3 GB of memory, Mapped files are using about 5 GB, 2.5 GB as Active and 2.5 GB standby.
The prolem is the OS system cache getting very huge. It's trying to caching a lot of files in memory.
When the amount of data is reaching about 500 Gb or server running for a long time then problems occur.
Installing the Domino fix don't solve the problem, backup or anti vira SW is also triggering it.
BR
Mov V Hansen
Feedback response number WEBB8NHGMS created by ~Rebecca Kijipyteretsi on 11/11/2011